When the adventurer Walter Ralegh first encountered Elizabeth I, he supposedly placed his cloak over a puddle and allowed the queen to walk across it. Thus began one of the most intriguing relationships between a monarch and her favourite. "The Favourite" explores the labyrinthine complexity of human emotion, ambition and ritual within the restricted confines of the Tudor court. Was the favourite a Machiavellian schemer who fooled the queen in her affections? Was Elizabeth willing to manipulate her courtier for her own ends? The Queen's affection for Ralegh would protect him but he would soon become the 'most hated man in England'. In "The Favourite", Mathew Lyons reveals a new portrait of an immortal relationship and a fascinating exploration of the many layers of love between Gloriana and Ralegh - courtier, chancer and privateer.
Napoleon Bonaparte is renowned as one of the greatest military commanders in history, and the central figure in so many of the events of the French Revolutionary and Napoleonic wars. Throughout the first decade of the 19th century he won battle after battle by wielding the Grande Armee decisively against the other powers of Europe - Prussia, Austria and Russia. Yet his fortunes changed in 1812 when the invasion of Russia wrecked his forces, and Napoleon suffered his final defeat at Waterloo in 1815.
Series: Advances in Cancer Research
Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. The first ACR volume came out in the year that Watson and Crick reported on the central dogma of biology, the DNA double helix. In the first 100 volumes are found many contributions by some of those who helped shape the revolution and who made many of the remarkable discoveries in cancer research that have developed from it.
About the Editors: Kenneth D. Tew, Medical University of South Carolina, Charleston, South Caroline, USA and Paul B. Fisher, VCU Institute of Molecular Medicine, Richmond, Virginia, USA.
Kenneth D. Tew, Professor and Chairman, Department of Cell and Molecular Pharmacology John C. West Chair of Cancer Research, Medical University of South Carolina, USA and Paul B. Fisher, Professor and Chairman, Department of Human and Molecular Genetics, Thelma Newmeyer Corman Chair in Cancer Research, Director, Virginia Commonwealth University, School of Medicine, Virginia, USA.
To view individual chapters for Advances in Cancer Research, please visit Science Direct.
Praise for the Series: "Excellent, highly informative, in-depth reviews. expertly written, up-to-date and well-referenced." - JOURNAL OF MEDICINAL CHEMISTRY
Most recent volume
Tesla, Inc. (TSLA)
The market rally is heating up as volatility calms down. Amazon leads three top techs near buy points. Tesla and Nio are on the move.
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The Russell 1000 Index is a market-capitalization-weighted index of the 1,000 largest publicly traded companies in the U.S. It represents approximately 92% of the total market capitalization of all listed stocks in the U.S. equity market. The Russell 1000 provided a total return of 39.9% over the past 12 months. Value investing is a factor-based investing strategy that involves picking stocks that you believe are trading for less than what they are intrinsically worth, usually by measuring the ratio of the stock's price to one or more fundamental business metrics.
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Transporting an individual in psychiatric crisis to an emergency department is often frustrating for both law enforcement and mental health professionals. To facilitate collaboration between police and mental heath professionals in crisis cases, some communities have developed prebooking diversion programs that rely on specialized crisis response sites where police can drop off individuals in psychiatric crisis and return to their regular patrol duties. These programs identify detainees with mental disorders and work with diversion staff, community-based providers, and the courts to produce a mental health disposition in lieu of jail. This paper describes three of the diversion programs participating in the Substance Abuse and Mental Health Services Administration jail diversion knowledge development application initiative that demonstrate the importance of specialized crisis response sites. The three programs are in Memphis, Tennessee Montgomery County, Pennsylvania and Multnomah County, Oregon. The authors describe important principles in the operation of these programs: being a highly visible, single point of entry having a no-refusal policy and streamlined intake for police cases establishing legal foundations to detain certain individuals ensuring innovative, intensive cross-training and linking clients to community services.
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One Piece, Volume 52: Roger and Rayleigh
For me, One Piece is best Manga ever written. The story always touch my heart, it is a combination of faithful friendship, laughter, loyalty and action.
Some people might find this manga as silly and pointless (I’ve heard this before) but they never truly read the Manga and therefore judging it simply from the cover. I’ve been in that position too…and thank God I finally looked beyond the cover and found the greatest adventure any Mangaka ever written.
More about One Piece at my blog http://bokuno For me, One Piece is best Manga ever written. The story always touch my heart, it is a combination of faithful friendship, laughter, loyalty and action.
Some people might find this manga as silly and pointless (I’ve heard this before) but they never truly read the Manga and therefore judging it simply from the cover. I’ve been in that position too…and thank God I finally looked beyond the cover and found the greatest adventure any Mangaka ever written.
Annnnd this volume will be introducing Navy Admiral Borsalino aka Kizaru!
The best introduction scene of an admiral since Admiral Kuzan&aposs. I mean, they are the strongest fighter in the marine, so they should have awesome introduction right? But, however Admiral Sakazuki&aposs introduction scene, was meh. But later for that!
Kizaru is one of my favorite marines in this series. So, basically in this volume, you will see Luffy did crazy stuff alongside with his crew, Hearts Pirate & Kid Pir Annnnd this volume will be introducing Navy Admiral Borsalino aka Kizaru!
The best introduction scene of an admiral since Admiral Kuzan's. I mean, they are the strongest fighter in the marine, so they should have awesome introduction right? But, however Admiral Sakazuki's introduction scene, was meh. But later for that!
Kizaru is one of my favorite marines in this series. So, basically in this volume, you will see Luffy did crazy stuff alongside with his crew, Hearts Pirate & Kid Pirates and also Kizaru versus the other 4 Supernovas. And the most heartbreaking scene in the end of this volume.
This is the best troll/fight scene by Borsalino.
One Piece #52: 5 Stars
[8.53 - phenomenal]
This Volume was incredible. I adore not only the side characters that we got to meet/spent time with but the plot is simply going crazy. The Crew is up against enemies that they cannot win against in their current state and even though I know what is going to happen (reread) I am still feeling all the tension. I love every single little nod to Zoros injuries from Thriller Bark and the way Sanji and Brook are trying to get him to stay put because they know One Piece #52: 5 Stars
[8.53 - phenomenal]
This Volume was incredible. I adore not only the side characters that we got to meet/spent time with but the plot is simply going crazy. The Crew is up against enemies that they cannot win against in their current state and even though I know what is going to happen (reread) I am still feeling all the tension. I love every single little nod to Zoros injuries from Thriller Bark and the way Sanji and Brook are trying to get him to stay put because they know he's on the brink of death.
Rayleigh is such an amazing character we got introduced to and Kizaru has made his appearance as well. We got more time with Law, Kidd, Hawkins, Drake and Co. (Am I close to crying everytime I see Killer because I am way too emotional about Killer because of current One Piece events? YES YES I AM)
This also had one of my favorite Moments/Quotes from the series - a scene between Luffy, Law and Kidd about their determination and dreams.
While I gave almost every chapter a 7 (Amazing!) or a 6 (really great.) this simply adds up to a 8 (phenomenal) Volume because of it's pacing and lack of any negative from me at all. + it simply gave me all the 5 Star feels so there is that.
So excited to continue this reread. The amount of comfort I felt while reading this Volume was insane - it was like a hug to me ♥ . more
Brilliant stuff, as usual HOWEVER, I cannot fail to point out how Rayleigh&aposs existence in this series annoys me a little bit. He knows where the goddamn One Piece is. Why is nobody asking the son of a bitch? Not only does he know where it is, he knows WHAT it is. It pisses me off that every single character isn&apost lining up to ask him about it. Why are other pirates not attempting to capture and torture him or something? Luffy even said that he doesn&apost want to be told, because that ruins th Brilliant stuff, as usual HOWEVER, I cannot fail to point out how Rayleigh's existence in this series annoys me a little bit. He knows where the goddamn One Piece is. Why is nobody asking the son of a bitch? Not only does he know where it is, he knows WHAT it is. It pisses me off that every single character isn't lining up to ask him about it. Why are other pirates not attempting to capture and torture him or something? Luffy even said that he doesn't want to be told, because that ruins the adventure. I'm sorry, but that's dumb. It's just kinda silly writing. Rayleigh knows all the secrets but let's not make his knowledge an important part of the plot because friendship and adventure. Stop. Somebody ask this man what the hell the One Piece is right now. Why is the World Government not after him if he has that information? Shouldn't he be target number one?
Okay, I'll stop ranting about Rayleigh, but I can go for days. This was a great volume with a lot of important content, I just wish Oda would flesh out Rayleigh's hidden knowledge a little bit more, and how that knowledge affects the world-building. . more
Luffy has a habit of getting himself involved in other people’s problems and endangering himself and his crew in the process. It’s always fine, though, because in the end they overcome whatever odds they’re up against and save the day. This time, however, things aren’t looking so good. After bringing the ire of the Navy upon the island of Sabaody last volume, Luffy and his crew find themselves up against the might of multiple Navy platoons and one of its admirals. The other pirates on the island Luffy has a habit of getting himself involved in other people’s problems and endangering himself and his crew in the process. It’s always fine, though, because in the end they overcome whatever odds they’re up against and save the day. This time, however, things aren’t looking so good. After bringing the ire of the Navy upon the island of Sabaody last volume, Luffy and his crew find themselves up against the might of multiple Navy platoons and one of its admirals. The other pirates on the island get involved and we get treated to a smorgasbord of bizarre and nonsensical abilities as all sorts of unique characters come into conflict with each other. It’s interesting seeing the temporary camaraderie between opposing crews as they find a common enemy - there’s a sense of honour and loyalty amongst these cutthroats and degenerates.
Luffy has to make a big call in this volume - to retreat. This time he can’t pull a new power out of thin air or count on a deus ex machina he has to run. The Straw Hats are scattered and beaten and it’s an exciting departure from the status quo. . more
Again, I don&apost write reviews for this series, I mostly take notes of where I&aposm up to in order to keep the stories straight in my head.
Lots of goodies here, and some epic awesomeness with regards to what happens right after Luffy destroys a Celestial dragon&aposs FACE.
- Two words: Silvers Rayleigh. There really isn&apost a more perfect word to describe this man than that of badass. And he shows it the minute he made his presence known (and boy, he makes quite an impressionable entrance!).
- They all event Again, I don't write reviews for this series, I mostly take notes of where I'm up to in order to keep the stories straight in my head.
Lots of goodies here, and some epic awesomeness with regards to what happens right after Luffy destroys a Celestial dragon's FACE.
- Two words: Silvers Rayleigh. There really isn't a more perfect word to describe this man than that of badass. And he shows it the minute he made his presence known (and boy, he makes quite an impressionable entrance!).
- They all eventually meet up at Rayleigh's place to talk shop. To get their ship coated, they need some time for Rayleigh to coat it, meaning three days at the earliest. So, naturally, in order to keep out of the Marines' way, they have to lay low. Easier said than done when you're part of Luffy's crew.
- There is some interesting back story with Rayleigh and the disbandment of the Roger pirates. Kind of sad, and I hope this isn't some parallel play on the future of the Straw Hat pirates. Though, Zoro, take note, that is the power you, as a first mate, will soon have. Very soon.
- The Marines are attempting to cramp up the Straw Hats' style, but to no avail, considering now Captain Kid and Trafalgar Law are helping Luffy up a bit. We see the skills of every one of the Supernovas, namely Eustace Kid's and Trafalgar Law's (Kid's Devil's Fruit is fantastic, just saying).
- The introduction of Admiral #2 (Kizaru) is put into play, which is pretty frightening, considering the underlying question is now "HOW DO YOU BEAT A GUY MADE OF LIGHT?!" I just don't see it happening anytime soon.
- The Pacifistas show up, creating a bit of trouble with regards to, well, everyone. I did love the Straw Hat collaboration against the Pacifista that they fought. To bad it wasn't enough, 'cause obviously, Kizaru joined the fray, and so did another Pacifista, and, ultimately, Kuma himself.
- Rayleigh taking some active participation in attempting to save Zoro was hella epic. I loved that people respected him, Marines included.
- I did not love the beating Zoro and the rest took. And the fact that he disappears in this volume is just. insane. The next volume is proving to be depressing.
- That said, I do love the chapter images once again. Yay for CP9! . more
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If you end up with a Mini Cooper Cabrio, it&aposs unlikely that someone else in your suburb would have the same car, which is not something you can say about brands like BMW, Mercedes-Benz or Audi any longer. So it certainly has the uniqueness factor going for it.
After a week of being driven around in the Cooper S Cabrio, my girlfriend is currently harassing me every five minutes about why we aren&apost buying one to keep. So it certainly has considerable female appeal.
Nonetheless, it&aposs certainly not just a &aposcute&apos car for girls. Any real car enthusiast would know the Mini Cooper is one of the better handling front-wheel drive cars money can buy. In fact, so strong is the sporting history of Mini Coopers that up until this year, they had their own race series (Mini Challenge) in Australia. How many apparent &aposhairdresser cars&apos do you know have had their own race series?
From the outside there is no mistaking a Mini Cooper. Its unique shape gives it enormous character and a great deal of credibility. With the roof off, you might expect the little thing to look a tad awkward but it&aposs actually well proportioned and looks great as it drives past you.
The roof (which is made of very hard-wearing textile material) is fully automated and takes just 15 seconds to open or close. Best of all, it can be operated at speeds of up to 30km/h. That means you can put the roof on or take it off at traffic lights as you get going. This is a rather unique feature for convertibles as most won&apost let you go past 5km/h before stopping the roof operation.
There is also the option of just opening the sliding roof (essentially a sunroof) without removing the entire roof frame and that can be done at speeds of up to 120 km/h. If you do happen to just want the sliding roof open it does tend to create a fair bit of wind-noise. Best to have the whole roof on or off.
With the roof off you can comfortably hold a conversation with a passenger at speeds up to 150km/h. As for any willing passenger crammed in one of the two rear seats, you&aposll converse ok until you get on to a highway where you&aposre likely to hear them but they&aposre unlikely to hear you.
Speaking of back seats, you can fit an adult in there semi-comfortably for short journeys so long as they, or the person sitting in-front, doesn&apost have long legs. The Mini is really a two-seater with the option of being able to carry an additional two friends when the time comes.
The rear seat backrests also fold down completely giving you a rather high 660 litres of luggage capacity, so you can even make a few trips to IKEA.
Driver and passenger are treated with cloth trim sports seats (upgradable to full leather for about $2500) that hold you in rather nicely.
The gigantic speedometer still takes centre stage inside but given that it sits outside of the driver&aposs field of vision, Mini has also included a digital speedometer in the instrument cluster.
Something else that you can get in your Mini Cooper Cabrio S (for an additional $300) is an 𠇊lways Open Timer”. It is literally an instrument that does nothing but report how long you&aposve been driving with the roof down. A bit of a gimmick.
The six-speaker stereo is actually rather good but for whatever reason you&aposll have to pay an extra $750 to have Bluetooth (phone only, no audio streaming) and USB interface. Something that should really be standard on a car like this. An extra $850 will get you a ten-speaker HiFi system. $2900 more for satellite navigation and add an extra $500 on top of that for voice control.
When it comes down to it, the options list is rather large and can get a little pricey at times. Even wanting a car alarm will set you back an additional $600. That&aposs one downside of European cars, they have an extensive list of options that are hard to resist.
Numbers and prices aside, if you really need convincing, simply get behind the wheel of a Mini Cooper S Cabrio, take the roof off and press the sport button. Engage drive (or pick first gear) and go for a spirited drive up a twisty mountain road. The hardtop Cooper S is a great car as is, without a roof the fun factor is doubled.
Around corners the little Mini behaves exceptionally despite noticeable torque-steer at times. Given the short wheel base and the Mini&aposs excellent dynamics, it&aposs momentary torque-steer can even be a little fun and certainly ads loads of character and makes for a fun drive.
The front makes use of MacPherson spring struts while the rear sits on multi-arm systems developed by BMW. Overall, it&aposs one neat package. If you want even better handling, simply tick the sport suspension box (+$440) and away you go.
When the sport button is engaged it modifies the gas pedal control map for more response from the engine while also improving steering response. I&aposd suggest you just leave it on at all times unless stuck in traffic.
The Mini Cooper S Cabrio reviewed was optioned with a six-speed automatic transmission which provides smooth gearshifts and quickly adapts to your driving style. If the Cooper S does get a little loose around tight corners the nanny control will cut in and ruin the fun. It&aposs at those times that the Mini will hold you back a little while before giving it all again. If you&aposre game, you can turn the nanny systems off or better yet, buy a manual and still turn the nanny systems off! Then you&aposll be having some serious fun.
Safety can be a concern when you&aposre in a convertible, given there is no roof to protect you in case of a roll over. The Mini Cooper Cabrio provides four airbags plus rollbars that electromechanically engage within just 150 milliseconds if the car&aposs systems detect an imminent roll over situation. A whole bunch of active safety features (or nanny controls) will also help to prevent accidents.
On the grand scheme of things, if you&aposre willing to pay a little more for the prestige and handling dynamics of a Mini, it&aposs hard to argue against a Cooper S Cabrio. I&aposd highly suggest you test drive the Audi A3 and Mazda MX-5 as well, just to get a feel and notice the difference.
The validity of the Hospital Anxiety and Depression Scale. An updated literature review
Objective: To review the literature of the validity of the Hospital Anxiety and Depression Scale (HADS).
Method: A review of the 747 identified papers that used HADS was performed to address the following questions: (I) How are the factor structure, discriminant validity and the internal consistency of HADS? (II) How does HADS perform as a case finder for anxiety disorders and depression? (III) How does HADS agree with other self-rating instruments used to rate anxiety and depression?
Results: Most factor analyses demonstrated a two-factor solution in good accordance with the HADS subscales for Anxiety (HADS-A) and Depression (HADS-D), respectively. The correlations between the two subscales varied from.40 to.74 (mean.56). Cronbach's alpha for HADS-A varied from.68 to.93 (mean.83) and for HADS-D from.67 to.90 (mean.82). In most studies an optimal balance between sensitivity and specificity was achieved when caseness was defined by a score of 8 or above on both HADS-A and HADS-D. The sensitivity and specificity for both HADS-A and HADS-D of approximately 0.80 were very similar to the sensitivity and specificity achieved by the General Health Questionnaire (GHQ). Correlations between HADS and other commonly used questionnaires were in the range.49 to.83.
Conclusions: HADS was found to perform well in assessing the symptom severity and caseness of anxiety disorders and depression in both somatic, psychiatric and primary care patients and in the general population.
Dawner Prince Electronics Pulse review
Rotating speaker cabinets has been an essential part of David Gilmour’s tone since the early 70s. There’s been many pedals over the years, trying to capture that elusive tone and some has indeed succeeded. The newest on the market is the Pulse from Dawner Prince Electronics. Here’s my review.
I’ve had the pleasure of playing through Leslie cabinets in the studio while recording and it’s quite the experience. Still, dragging a Leslie on tour is a real hassle, so enter the pedals.
I have no idea what it takes to create a pedal as far as the electronics go but what I do know is that a rotating speaker isn’t really an effect like a distortion or a delay. It’s more a physical phenomenon that occur when sound moves. Some rotary pedals sound like a chorus and are not very convincing. Others have manage to capture that physical 3 dimensional character.
The Pulse is, as the name implies, based on David Gilmour’s custom Doppola open speaker rotating cabinets that he used during the 1994 Division Bell tour. These had two 6 inch 100w speakers each and were based on the Gibson Maestro Rover that David used for recording Division Bell. Read more about the Doppolas here.
This strange looking satellite Maestro Rover sounded very different from a classic Leslie. While a Leslie has a rotating horn and a distinct tremolo-like modulation, the Doppolas and Rover had a much more airy, almost flange-like tone. David would blend in just a hint of that modulated character to his dry amps and pedals. Read more about the Maestro Rover here.
If you’re mostly used to hearing a Leslie or pedals like the Strymon Lex, you might need some time getting used to the Pulse. It sound very different but, spot on what it’s supposed to do.
The pedal is about the size of a MXR Flanger, with controls for controlling the fast and slow speeds individually, mic distance to the speakers, ramp up/down between slow and fast and a mix or effect volume. It can run in both stereo and mono and is powered on 9V adapter.
It can be hard to notice the rotary modulation on David’s guitars on Division Bell and Pulse but’s definitely there. It’s not supposed to be an overly noticeable effect but rather something that adds character to his tones. The Endless River album is perhaps a better reference, where the original guitar tracks from 1993 are much more honest sounding compared to the fairly heavily produced Divison Bell.
The Pulse manages to capture that airy, almost 3D like tone. Even in mono, the pedal adds a huge complex texture to your tones, something between a Leslie and an Electric Mistress flanger.
The mix control allow you to blend in the right amount of the effect, whether you want just a hint of that slow rotary or a deep fast speed tremolo. It can handle high gain distortions and Big Muffs very well too.
I’m super impressed over the Pulse. It’s a bold pedal to make as it is so clearly modelled after a specific and rather obscure rotating speaker model. This is obviously not just another attempt at making a Leslie sounding pedal but a super accurate replication of a sound unique to David Gilmour.